Dimension Reduction

Discovering structural units of chromosomal organization with matrix factorization and graph regularization

Upcoming talk - see you in Basel!

Discovering structural units of chromosomal organization with matrix factorization and graph regularization

Three dimensional organization of the genome is emerging as an important determinant of cell-type specific expression and is implicated in many diseases, including cancer (Bouwman & de Laat 2015). Hi-C is a type of high-throughput chromosome …

Higher Understanding with Lower Dimensions

Tutorial on dimension reduction methods at the Great Lakes Bioinformatics (GLBIO) conference

GRINCH: Discovering structural units of chromosomes with graph-regularized matrix factorization

Three dimensional organization of the genome is emerging as an important determinant of cell-type specific expression and is implicated in many diseases, including cancer (Bouwman & de Laat 2015). Hi-C is a type of high-throughput chromosome …

A graph-regularized non-negative matrix factorization method to discover organizational units of chromosomes

Three dimensional organization of the genome is emerging as an important determinant of cell-type specific expression and is implicated in many diseases, including cancer. Hi-C is a type of high-throughput chromosome conformation capture (3C) assay …

Higher Understanding with Lower Dimensions

Dimension Reduction Tutorial at GLBIO 2019